Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

@article{Hogan1997AeroallergeninducedEI,
  title={Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.},
  author={Simon P Hogan and Arne W Mould and Hitoshi Kikutani and Alistair J Ramsay and Paul S Foster},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 6},
  pages={1329-39}
}
In this investigation we have used a mouse model containing certain phenotypic characteristics consistent with asthma and IL-4- and CD40-deficient mice to establish the role of this cytokine and allergen-specific immunoglobulins in the initiation of airways hyperreactivity and morphological changes to the airways in responses to aeroallergen challenge. Sensitization and aerosol challenge of mice with ovalbumin resulted in a severe airways inflammatory response which directly correlated with the… CONTINUE READING

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Disruption of the murine IL-4 gene blocks Th2 cytokine responses

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