Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.

@article{Salas2008Ae2abdeficientMD,
  title={Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.},
  author={January T. Salas and Jes{\'u}s Mar{\'i}a Banales and Sarai Sarvide and Sergio Recalde and Alex Ferrer and Iker Uriarte and Ronald P. J. Oude Elferink and Jes{\'u}s Prieto and Juan Francisco Medina},
  journal={Gastroenterology},
  year={2008},
  volume={134 5},
  pages={
          1482-93
        }
}
BACKGROUND & AIMS Cl(-)/HCO(3)(-) anion exchanger 2 (AE2) is involved in intracellular pH (pH(i)) regulation and transepithelial acid-base transport, including secretin-stimulated biliary bicarbonate excretion. AE2 gene expression was found to be reduced in liver biopsy specimens and blood mononuclear cells from patients with primary biliary cirrhosis (PBC), a disease characterized by chronic nonsuppurative cholangitis associated with antimitochondrial antibodies (AMA) and other autoimmune… CONTINUE READING
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Molecular physiology of SLC4 anion exchangers.

Experimental physiology • 2006
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