Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor.

@article{Westendorp2009AdverseRE,
  title={Adverse renal effects of hydrochlorothiazide in rats with myocardial infarction treated with an ACE inhibitor.},
  author={Bart Westendorp and Inge Hamming and Mariusz K. Szymanski and Gerjan Navis and Harry van Goor and Hendrik J Buikema and Wiek H van Gilst and Regien Geertruida Schoemaker},
  journal={European journal of pharmacology},
  year={2009},
  volume={602 2-3},
  pages={373-9}
}
Diuretics, when added to angiotensin-converting enzyme inhibitors (ACE inhibitors) treatment, can augment the response to ACE inhibitors, but may have adverse effects on renal function, which negatively affect prognosis. While in heart failure rats combined therapy initially improved cardiac function and prognosis, this benefit was completely lost at later… CONTINUE READING