Adverse reactions to vancomycin used as prophylaxis for CSF shunt procedures.

  title={Adverse reactions to vancomycin used as prophylaxis for CSF shunt procedures.},
  author={C N Odio and Edgar Mohs and F H Sklar and John Daniel Nelson and George H Mccracken},
  journal={American journal of diseases of children},
  volume={138 1},
From January to May 1982, 37 children undergoing CSF shunt procedures in two different countries were enrolled in a randomized, double-blind, controlled study to receive vancomycin hydrochloride (15 mg/kg/dose) or placebo (saline) one hour before surgery and again six hours later. Twenty patients received vancomycin, and 17 received placebo. In the 35 cases that could be evaluated, shunt-associated infections developed in three (17%) of 18 patients who received vancomycin and in four (23%) of… CONTINUE READING

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