Adverse reactions to metal on polyethylene implants: Highly destructive lesions related to elevated concentration of cobalt and chromium in synovial fluid.

@article{Eltit2017AdverseRT,
  title={Adverse reactions to metal on polyethylene implants: Highly destructive lesions related to elevated concentration of cobalt and chromium in synovial fluid.},
  author={Felipe Eltit and Ali H Assiri and Donald Garbuz and Clive P. Duncan and Bassam S Masri and Nelson V Greidanus and Robert H. Bell and Manju Sharma and Michael E. Cox and Rizhi Wang},
  journal={Journal of biomedical materials research. Part A},
  year={2017},
  volume={105 7},
  pages={1876-1886}
}
Adverse local tissue reactions (ALTR) are the primary cause of failure of metal on metal (MoM) hip implants, and fewer but not negligible number cases of nonmodular metal on polyethylene (MoP) implants. In this study, we analyzed 17 cases of MoP ALTR, and equal number of MoM, by histological observation, cobalt and chromium concentration in serum and synovial fluid and cytokine analysis in ALTR tissues. ALTRs in MoP are highly necrotic, affecting larger areas than MoM ALTRs. Degenerative… CONTINUE READING