Adverse reactions to intravenous iodinated contrast media: a primer for radiologists

@article{Namasivayam2006AdverseRT,
  title={Adverse reactions to intravenous iodinated contrast media: a primer for radiologists},
  author={Saravanan Namasivayam and Mannudeep K. Kalra and William E. Torres and William C. Small},
  journal={Emergency Radiology},
  year={2006},
  volume={12},
  pages={210-215}
}
Adverse reactions to intravenous iodinated contrast media may be classified as general and organ-specific, such as contrast-induced nephrotoxicity. General adverse reactions may be subclassified into acute and delayed types. Acute general adverse reactions can range from transient minor reactions to life-threatening severe reactions. Non-ionic contrast media have lower risk of mild and moderate adverse reactions. However, the risk of fatal reactions is similar for ionic and non-ionic contrast… Expand

Paper Mentions

Late adverse reactions to intravascular iodine based contrast media: an update
TLDR
The main risk factors for LAR are a previous reaction to contrast medium, a history of allergy, and interleukin-2 treatment, and most skin reactions are mild or moderate and self-limiting. Expand
Prevention and Management of Adverse Reactions Induced by Iodinated Contrast Media.
TLDR
The pathophysiology, epidemiology and risk factors of ADRs with emphasis on prevention and treatment strategies are summarised to allow readers to understand the rationale behind appropriate patient preparation for diagnostic imaging involving IRCM. Expand
Allergic reactions to iodinated contrast media: premedication considerations for patients at risk
The objectives of this article are to review allergy-type reactions to iodinated contrast media and the protocols utilized to prevent or reduce the occurrence of these adverse reactions in high-riskExpand
Adverse Reactions from Contrast Media in Patients Undergone Computed Tomography at the Department of Radiology, Srinagarind Hospital
TLDR
Mild to moderate adverse reactions to low-osmolar contrast media were most common and these occurred immediately after administration and for patient safety and better outcomes, improving the identification of patients likely to have an adverse reaction is essential. Expand
Patients at high risk of adverse events from intravenous contrast media after computed tomography examination
TLDR
As the number of patients undergoing computed tomography procedures continues to increase, it is essential for physicians to be able to identify patients at risk for adverse events of CM. Expand
Adverse reactions following administration of contrast media for diagnostic imaging in anaesthetized dogs and cats: a retrospective study.
TLDR
Severe reactions to io hexol and gadobutrol are rare in dogs and cats; moderate reactions are more likely with iohexol than with gadobutsrol; and these estimates did not change substantially after adjustment for age, weight and sex. Expand
Adverse Effects of Iodine-derived Intravenous Radiopaque Contrast Media.
Although the advent of nonionic low-osmolar contrast agents has reduced the probability of a reaction to radiopaque contrast media derived from tri-iodinated benzoic acid, reactions still occur.Expand
Safe Use of Contrast Media: What the Radiologist Needs to Know.
TLDR
Current knowledge for safe use of contrast media and key concepts that all radiologists should know are summarized in this review. Expand
Clinical observation of adverse drug reactions to non-ionic iodinated contrast media in population with underlying diseases and risk factors.
TLDR
The incidence of ADRs was extremely low in patients regardless of underlying diseases, and particular attention should be given to patients at high risk when performing enhanced CT examination. Expand
A study of adverse drug reactions to radio contrast media in a tertiary care teaching rural hospital
TLDR
It is recommended to use non-ionic contrast media instead of ionic media by all the health care professionals and treatment with steroids and antihistaminic in patients who develop ADRs due to radiocontrast media can be effective. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Adverse reactions to iodinated contrast media
TLDR
The use of ICM in diabetic patients receiving metformin should be carried out with care to avoid met formin-induced lactic acidosis, and contrast-media-induced renal impairment can be reduced with the use of low-osmolality contrast media and extracellular volume expansion. Expand
Late adverse reactions to intravascular iodinated contrast media
TLDR
The Contrast Media Safety Committee of the European Society of Urogenital Radiology decided to review the literature and to issue guidelines and an extensive literature search was carried out, and simple guidelines have been drawn up. Expand
Adverse Effects of Contrast Media
Although contrast media are relatively well tolerated, a non-life-threatening, moderate reaction requiring some treatment occurs in 1 to 2% of patients receiving ionic high-osmolar contrast media andExpand
Reactions to urographic contrast media.
TLDR
A large body of clinical and experimental data has accumulated during the nearly 50 years since intravenous contrast media were first introduced into clinical medicine, but the cause of reactions remains obscure. Expand
Rates of Idiosyncratic Reactions Ionic versus Nonionic Contrast Media
  • R. Siegle
  • Chemistry, Medicine
  • Investigative radiology
  • 1993
TLDR
Most evidence demonstrates that nonionic agents are safer than ionic agents, and two analytical reviews of earlier research find fault with the methodology of most studies, but the reviewers supported the increased safety ofnonionic agents. Expand
Is there a role for corticosteroid prophylaxis in patients at increased risk of adverse reactions to intravascular contrast agents?
TLDR
A large scale study of ionic contrast agents alone, ionic Contrast agents combined with corticosteroid prophylaxis and non-ionic agents alone found that steroid premedication did indeed provide some protection but the use of a non-ionics alone was significantly better for prevention of the occurrence of all categories of reactions. Expand
Pretreatment with corticosteroids to alleviate reactions to intravenous contrast material.
TLDR
It is concluded that the much less expensive ionic medium, if administered with corticosteroid pretreatment, may serve as a reasonable alternative to intravenous nonionic medium, without loss of safety. Expand
Radiographic contrast media studies in high-risk patients.
TLDR
Pretreatment decreases the risk in this population of patients and is recommended as standard prophylaxis for patients requiring RCM who have had a previous AR and who had an essential need for a repeat RCM study. Expand
Pretreatment with corticosteroids to prevent adverse reactions to nonionic contrast media.
TLDR
A rigidly controlled study of the potential protective effects of a two-dose oral corticosteroid regimen preceding IV injection of nonionic contrast medium indicates that corticosterone pretreatment confers significant protection, at least for overall reactions and grade I reactions. Expand
Prevention of generalized reactions to contrast media: a consensus report and guidelines
TLDR
The aim of this study was to identify areas where there is disagreement or confusion and to draw up guidelines for reducing the risk of generalized contrast media reactions based on the survey and a review of the literature. Expand
...
1
2
3
4
...