Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

@article{Hakimi2013AdverseOI,
  title={Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.},
  author={Abraham Ari Hakimi and Irina Ostrovnaya and Boris Reva and Nikolaus Schultz and Ying-Bei Chen and Mithat Gonen and Han Liu and Shugaku Takeda and Martin H Voss and Satish K. Tickoo and Victor E. Reuter and Paul Russo and Emily H-Y Cheng and Chris Sander and Robert J Motzer and James J Hsieh},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 12},
  pages={
          3259-67
        }
}
PURPOSE To investigate the impact of newly identified chromosome 3p21 epigenetic tumor suppressors PBRM1, SETD2, and BAP1 on cancer-specific survival (CSS) of 609 patients with clear cell renal cell carcinoma (ccRCC) from 2 distinct cohorts. EXPERIMENTAL DESIGN Select sequencing on 3p tumor suppressors of 188 patients who underwent resection of primary ccRCC at the Memorial Sloan-Kettering Cancer Center (MSKCC) was conducted to interrogate the genotype-phenotype associations. These findings… CONTINUE READING

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