Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia.

@article{Rafeq2013AdverseME,
  title={Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia.},
  author={Z Rafeq and Jason D. Roh and Peter Guarino and James Kaufman and Joshinth Joseph},
  journal={Nutrition, metabolism, and cardiovascular diseases : NMCD},
  year={2013},
  volume={23 9},
  pages={836-42}
}
BACKGROUND & AIMS Hyperhomocysteinaemia (HHCY), a common finding in patients with chronic kidney disease (CKD), has been shown to contribute to adverse cardiac remodelling and failure. We hypothesised that in human subjects with CKD, HHCY would be associated with myocardial dysfunction, and that homocysteine (HCY)-lowering therapy would improve myocardial remodelling and heart-failure (HF) outcomes. METHODS AND RESULTS Post hoc analysis of the Homocysteinemia in Kidney and End Stage Renal… CONTINUE READING
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