Adverse mortality effect of central sympathetic inhibition with sustained‐release moxonidine in patients with heart failure (MOXCON)

@article{Cohn2003AdverseME,
  title={Adverse mortality effect of central sympathetic inhibition with sustained‐release moxonidine in patients with heart failure (MOXCON)},
  author={Jay Norman Cohn and Marc A. Pfeffer and Jean L. Rouleau and Norman Sharpe and Karl Swedberg and Matthias Straub and Curtis G. Wiltse and Theressa J. Wright},
  journal={European Journal of Heart Failure},
  year={2003},
  volume={5}
}
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330 Citations
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330 Citations

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References

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TLDR
Plasma norepinephrine was markedly reduced in a dose-related manner by moxonidine SR, accompanied by evidence of reverse remodeling, but also by an increase in adverse events.
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TLDR
Resting of the heart by decreasing heart rate, systemic arterial blood pressure, and venous tone are thought by the authors to be major contributing factors to the observed beneficial effect of chronic oral clonidine in chronic heart failure.
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