Adverse interactions between antifungal azoles and vincristine: review and analysis of cases.

@article{Moriyama2012AdverseIB,
  title={Adverse interactions between antifungal azoles and vincristine: review and analysis of cases.},
  author={Brad Moriyama and Stacey A Henning and Janice Kwan-Wai Leung and O Falade-Nwulia and Paul F Jarosinski and Scott R. Penzak and Thomas J Walsh},
  journal={Mycoses},
  year={2012},
  volume={55 4},
  pages={
          290-7
        }
}
Triazole and imidazole antifungal agents inhibit metabolism of vincristine, leading to excess vinca alkaloid exposure and severe neurotoxicity. Recent reports of debilitating interactions between vincristine and itraconazole, as well as posaconazole, voriconazole and ketoconazole underscore the need to improve medical awareness of this adverse combination. We, therefore, undertook a comprehensive analysis of reports of adverse drug interactions (ADIs) with the combination of vincristine and… CONTINUE READING