Adverse influence of systemic vascular stiffening on cardiac dysfunction and adaptation to acute coronary occlusion.


BACKGROUND [corrected] Age is an independent risk factor for increased mortality from ischemic heart disease. Arterial stiffening with widening of the pulse pressure may contribute to this risk by exacerbating cardiac dysfunction after total coronary artery occlusion. METHODS AND RESULTS To test the above hypothesis, 14 open-chest dogs underwent surgery… (More)