Adverse events to nontargeted and targeted chemotherapeutic agents: emphasis on hypersensitivity responses.

@article{Baldo2014AdverseET,
  title={Adverse events to nontargeted and targeted chemotherapeutic agents: emphasis on hypersensitivity responses.},
  author={Brian A Baldo and Mauro Pagani},
  journal={Immunology and allergy clinics of North America},
  year={2014},
  volume={34 3},
  pages={565-96, viii}
}
Use of cytotoxic agents is associated with potential hypersensitivity reactions which are common with platinum compounds, L-asparaginase, taxanes, procarbazine and epipodophyllotoxins. Mechanisms underlying the reactions may involve IgE, non-allergic or a number of pathogenetically unclear events. Targeted therapies produce less collateral damage but… CONTINUE READING