Adverse events of standardized regimens of corticosteroids for prophylaxis and treatment of nerve function impairment in leprosy: results from the 'TRIPOD' trials.

@article{Richardus2003AdverseEO,
  title={Adverse events of standardized regimens of corticosteroids for prophylaxis and treatment of nerve function impairment in leprosy: results from the 'TRIPOD' trials.},
  author={Jan Hendrik Richardus and Stephen G Withington and Alison M. Anderson and Richard P Croft and Peter G. Nicholls and Wim H van Brakel and William Cairns S. Smith},
  journal={Leprosy review},
  year={2003},
  volume={74 4},
  pages={319-27}
}
Reactions in leprosy causing nerve function impairment (NFI) are increasingly treated with standardized regimens of corticosteroids, often under field conditions. Safety concerns led to an assessment of adverse events of corticosteroids, based on data of three trials studying prevention of NFI (the TRIPOD study). A multicentre, randomized, double-blind placebo-controlled trial was conducted in leprosy control programmes in Nepal and Bangladesh. Treatment was with prednisolone according to fixed… CONTINUE READING

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