Adverse events following immunization: perception and evidence

  title={Adverse events following immunization: perception and evidence},
  author={Jan Bonhoeffer and Ulrich Heininger},
  journal={Current Opinion in Infectious Diseases},
Purpose of review The aim of this article is to highlight the evidence on new and ongoing vaccine safety concerns in the light of several vaccines recently licensed and others made available and recommended more widely. Recent findings There is increasingly convincing epidemiologic and laboratory evidence against a causal relation of several alleged adverse events following immunization. The scientific framework to detect and investigate adverse events following immunization is increasingly… 
Perceptions of vaccine safety in a global context
A short review of some recent studies of parental decision‐making on vaccination in developed countries Kazaktstan, Uzbekistan and Northern Nigeria and an attempt is made to relate the findings in these studies to theoretical models of parents' decision-making.
Vaccination safety update.
The safety profile of modern vaccines and their continuous surveillance is discussed and it is shown why the current criticism of vaccination on safety grounds is unjustified.
Current status and future directions of post-marketing vaccine safety monitoring with focus on USA and Europe.
Surveillance for Adverse Events following Immunization from 2008 to 2011 in Zhejiang Province, China
ABSTRACT This study summarizes passive surveillance data for adverse events following immunization (AEFI) reported to the National AEFI Surveillance System (NASS) in Zhejiang province and describes
Adjuvants in malaria vaccine development strategies: a review
Limits of various antigens in conjunction with adjuvants used are highlighted and insight is provided on new strategies of improving vaccine immunogenicity by incorporating immunomodulatory molecules and epitopes.
Pertussis in infants: options for prevention
  • Medicine
  • 2008
This bibliography contains every paper annotated by reviewers; these references were obtained from a variety of bibliographic databases and published between the beginning of the review period and the time of going to press.


A global perspective on vaccine safety and public health: the Global Advisory Committee on Vaccine Safety.
The Global Advisory Committee on Vaccine Safety is highlighted, including the purported link between the measles-mumps-rubella vaccine and autism and the safety of the mumps, influenza, yellow fever, BCG, and smallpox vaccines as well as that of thiomersal-containing vaccines.
Does antigenic overload exist? The role of multiple immunizations in infants.
  • A. Gregson, R. Edelman
  • Medicine, Political Science
    Immunology and allergy clinics of North America
  • 2003
We will have to vaccinate healthy children against influenza when we know that it is helpful
Evidence for the efficacy of inactivatedinfluenza vaccine in infants and young children, the groupproposed for the intervention, is too scarce to be proved and this may be the main point against their finalrecommendation.
Acute infections, infection pressure, and atopy
This work investigated associations between acute infections, infection pressure (i.e. number of daily child contacts) and atopy in one of the largest population‐based medical surveys ever published in the medical literature.
A potential signal of Bell's palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS)—United States, 1991–2001 ,
Reports in the Vaccine Adverse Event Reporting System (VAERS) were reviewed to assess if parenteral inactivated influenza vaccines (influenza vaccines) may also increase the risk for Bell's palsy.
Withdrawal of rotavirus vaccine recommendation.
  • Medicine
    MMWR. Morbidity and mortality weekly report
  • 1999
In July 1999, CDC recommended that health-care providers and parents postpone use of the rhesus rotavirus vaccine-tetravalent (RRV-TV) (RotaShield, Wyeth Laboratories, Inc., Marietta, Pennsylvania),
Hepatitis B vaccines.
Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps rubella vaccine in the United States.
No substantial increase in the number of reported allergic events after frequently used gelatin containing MMR and varicella vaccines could be observed during the first 4 years (1997-2000) since the introduction of diphtheria-tetanus-acellular pertussis vaccines for use in infancy.