Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program.

@article{Pulsipher2009AdverseEA,
  title={Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National Marrow Donor Program.},
  author={Michael A Pulsipher and Pintip Chitphakdithai and J. Phillip Miller and Brent R Logan and Roberta J King and James Douglas Rizzo and Susan F. Leitman and Paolo Anderlini and Michael D. Haagenson and Seira Kurian and John P. Klein and Mary M. Horowitz and Dennis L. Confer},
  journal={Blood},
  year={2009},
  volume={113 15},
  pages={3604-11}
}
Limited data are available describing donor adverse events (AEs) associated with filgrastim mobilized peripheral blood stem cell (PBSC) collections in unrelated volunteers. We report results in 2408 unrelated PBSC donors prospectively evaluated by the National Marrow Donor Program (NMDP) between 1999 and 2004. Female donors had higher rates of AEs, requiring central line placement more often (17% vs 4%, P< .001), experiencing more apheresis-related AEs (20% vs 7%, P< .001), more bone pain (odds… CONTINUE READING
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