Adverse effects of prolactin in rodents and humans: breast and prostate cancer.

  title={Adverse effects of prolactin in rodents and humans: breast and prostate cancer.},
  author={Philip W Harvey and David J Everett and Christopher J Springall},
  journal={Journal of psychopharmacology},
  volume={22 2 Suppl},
Drugs and chemicals shown to induce mammary carcinogenesis in the rat/rodent via prolactin excess have traditionally been argued to pose little or no risk to humans in a regulatory toxicology context. The basis for this assumption is reviewed and placed into context with new evidence in humans that prolactin may be a tumour promoter in the breast and prostate. This evidence includes epidemiology, patient studies involving endocrine evaluation and molecular biology in human cells. It is… CONTINUE READING
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