Adverse effects of lidocaine and methylparaben on tracheal ciliary activity.

@article{Mostow1979AdverseEO,
  title={Adverse effects of lidocaine and methylparaben on tracheal ciliary activity.},
  author={S R Mostow and R B Dreisin and B R Manawadu and F Marc Laforce},
  journal={The Laryngoscope},
  year={1979},
  volume={89 10 Pt 1},
  pages={1697-701}
}
The effect of standard concentrations of lidocaine HCl and methylparaben (preservative) on the ciliary activity of ferret tracheal rings in organ culture was assessed. Pure lidocaine concentrations as low as 0.5% caused complete ciliostasis which was reversible after removal of the drug. One percent and two percent effects were not completely reversible. Pure methylparaben concentrations as low as 0.06 mg/ml paralyzed cilia; and, at concentrations of 0.5 mg/ml or higher, adverse effects were… CONTINUE READING