Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary artery diameter in an experimental model.

@article{Hale1989AdverseEO,
  title={Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary artery diameter in an experimental model.},
  author={Sharon L. Hale and Kevin J. Alker and Shereif H. Rezkalla and G Figures and Robert A. Kloner},
  journal={American heart journal},
  year={1989},
  volume={118 5 Pt 1},
  pages={
          927-33
        }
}
Smoking "crack" is currently popular; this results in rapidly peaking, high blood levels of cocaine. Our purpose was to investigate the effects of rapid cocaine administration. Hemodynamics, myocardial blood flow, and left ventricular cavity end-systolic and end-diastolic areas were measured in pentobarbital-anesthetized dogs before and 15 minutes after (1) a bolus intravenous injection of cocaine (n = 6), or (2) a 10-minute infusion of cocaine (n = 6), or (3) saline (n = 6) administration. In… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Cardiovascular toxicity of cocaine: underlying mechanisms.

VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Acute and Chronic Effects of Cocaine on Cardiovascular Health

VIEW 1 EXCERPT
CITES BACKGROUND

Mechanisms of toxic cardiomyopathy.

VIEW 1 EXCERPT
CITES BACKGROUND

The Cardiovascular Effects of Cocaine.

VIEW 1 EXCERPT
CITES BACKGROUND

Cardiovascular consequences of cocaine use.

VIEW 2 EXCERPTS
CITES BACKGROUND