Adverse effects of antiepileptic drugs

@article{Perucca2012AdverseEO,
  title={Adverse effects of antiepileptic drugs},
  author={Piero Perucca and Frank G Gilliam},
  journal={The Lancet Neurology},
  year={2012},
  volume={11},
  pages={792-802}
}

The Long-Term Safety of Antiepileptic Drugs

TLDR
Physicians should not only be aware of the late and chronic AEs of AEDs but should systematically enquire and screen for these according to the individual AED AE profile, and care should be taken for individuals with comorbid conditions that may render them more susceptible to specific AEs.

Tolerability and Safety of Commonly Used Antiepileptic Drugs in Adolescents and Adults: A Clinician’s Overview

TLDR
The issues surrounding the tolerability and safety of the commonly used antiepileptic drugs (AEDs) in adolescents and adults are discussed, including dose-related adverse effects, idiosyncratic reactions, behavioural and psychiatric comorbidities, chronic problems, enzyme induction and teratogenesis.

Safety aspects of antiepileptic drugs—a population-based study of adverse effects relative to changes in utilisation

TLDR
This study demonstrates that most adverse effects reported concerned AEDs increasingly used in non-epilepsy indications: neuropathic pain (pregabalin, gabapentin, carbamazepine) and psychiatry (lamotrigine, valproate, carbazepine).
...

References

SHOWING 1-10 OF 98 REFERENCES

Adverse effects of antiepileptic drugs

TLDR
Adverse effects of antiepileptic drugs (AEDs) are common, can have a considerable impact on quality of life and contribute to treatment failure in up to 40% of patients, whereas the potential teratogenicity of new generation AEDs is largely unknown.

Adverse effects of antiepileptic drugs: a brief overview of important issues

TLDR
Three categories of prevalent adverse effects (CNS, behavioral and general medical issues) are described comparing profiles of second- and third-generation AEDs.

CNS Adverse Events Associated with Antiepileptic Drugs

TLDR
This review discusses the available literature and provides a comprehensive summary of adverse drug reactions of AEDs affecting the CNS and recommends careful dose titration with small initial doses to reduce the likelihood of these adverse effects occurring.

Adverse antiepileptic drug effects in new-onset seizures

TLDR
When AED treatment is started at low doses following new-onset seizures, AE reporting does not differ from untreated individuals, and targeting specific factors affecting AE reporting could lead to improved tolerability of epilepsy treatment.

Neuropsychological and Behavioral Effects of Antiepilepsy Drugs

TLDR
The present article serves to provide an overview of the current understanding regarding the risks of antiepilepsy drug use for both cognitive and behavioral side effects.

Clinically relevant drug interactions with antiepileptic drugs.

  • E. Perucca
  • Medicine, Biology
    British journal of clinical pharmacology
  • 2006
TLDR
Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs), and pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy.

Adverse antiepileptic drug effects

TLDR
Adverse effects of antiepileptic drugs can be classified in five biologically plausible factors and when specific classes of AEs are identified and attempts are made to reduce them, quality of life is significantly improved.

Genetic basis for idiosyncratic reactions to antiepileptic drugs

TLDR
This article will focus on recent findings concerning genetic factors affecting susceptibility to idiosyncratic reactions to antiepileptic drugs, and the recommendation that patients of Asian ancestry be tested for the HLA-B*1502 allele.
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