Adverse effects of antiepileptic drugs

@article{Perucca2012AdverseEO,
  title={Adverse effects of antiepileptic drugs},
  author={Piero Perucca and Frank G Gilliam},
  journal={The Lancet Neurology},
  year={2012},
  volume={11},
  pages={792-802}
}
More than 150 years after bromide was introduced as the first antiepileptic drug, adverse effects remain a leading cause of treatment failure and a major determinant of impaired health-related quality of life in people with epilepsy. Adverse effects can develop acutely or many years after starting treatment and can affect any organ or structure. In the past two decades, many efforts have been made to reduce the burden of antiepileptic drug toxicity. Several methods to screen and quantify… Expand
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References

SHOWING 1-10 OF 98 REFERENCES
Adverse effects of antiepileptic drugs
TLDR
Adverse effects of antiepileptic drugs (AEDs) are common, can have a considerable impact on quality of life and contribute to treatment failure in up to 40% of patients, whereas the potential teratogenicity of new generation AEDs is largely unknown. Expand
Adverse effects of antiepileptic drugs: a brief overview of important issues
TLDR
Three categories of prevalent adverse effects (CNS, behavioral and general medical issues) are described comparing profiles of second- and third-generation AEDs. Expand
CNS Adverse Events Associated with Antiepileptic Drugs
TLDR
This review discusses the available literature and provides a comprehensive summary of adverse drug reactions of AEDs affecting the CNS and recommends careful dose titration with small initial doses to reduce the likelihood of these adverse effects occurring. Expand
Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs
TLDR
Careful monitoring of clinical response is recommended whenever a drug is added or removed from a patient's AED regimen. Expand
Adverse antiepileptic drug effects in new-onset seizures
TLDR
When AED treatment is started at low doses following new-onset seizures, AE reporting does not differ from untreated individuals, and targeting specific factors affecting AE reporting could lead to improved tolerability of epilepsy treatment. Expand
Strategies to detect adverse effects of antiepileptic drugs in clinical practice
TLDR
The use of an active approach is recommended for detection of AEs of AED treatment in patients treated with antiepileptic drugs according to the strategies used by the neurologist to detect them. Expand
Neuropsychological and Behavioral Effects of Antiepilepsy Drugs
TLDR
The present article serves to provide an overview of the current understanding regarding the risks of antiepilepsy drug use for both cognitive and behavioral side effects. Expand
Clinically relevant drug interactions with antiepileptic drugs.
  • E. Perucca
  • Medicine
  • British journal of clinical pharmacology
  • 2006
TLDR
Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs), and pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy. Expand
Adverse antiepileptic drug effects
TLDR
Adverse effects of antiepileptic drugs can be classified in five biologically plausible factors and when specific classes of AEs are identified and attempts are made to reduce them, quality of life is significantly improved. Expand
Genetic basis for idiosyncratic reactions to antiepileptic drugs
TLDR
This article will focus on recent findings concerning genetic factors affecting susceptibility to idiosyncratic reactions to antiepileptic drugs, and the recommendation that patients of Asian ancestry be tested for the HLA-B*1502 allele. Expand
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