Adverse effects of anticancer agents that target the VEGF pathway

  title={Adverse effects of anticancer agents that target the VEGF pathway},
  author={Helen X. Chen and Jessica N. Cleck},
  journal={Nature Reviews Clinical Oncology},
  • Helen X. Chen, Jessica N. Cleck
  • Published 2009
  • Medicine
  • Nature Reviews Clinical Oncology
  • Antiangiogenesis agents that target the VEGF/VEGF receptor pathway have become an important part of standard therapy in multiple cancer indications. With expanded clinical experience with this class of agents has come the increasing recognition of the diverse adverse effects related to disturbance of VEGF-dependent physiological functions and homeostasis in the cardiovascular and renal systems, as well as wound healing and tissue repair. Although most adverse effects of VEGF inhibitors are… CONTINUE READING

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