Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees

@article{Mi2003AdverseEO,
  title={Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees},
  author={Zhibao Mi and Steven C. Ghivizzani and Eric R. Lechman and Joseph Charles Glorioso and Christopher H. Evans and Paul D. Robbins},
  journal={Arthritis Research & Therapy},
  year={2003},
  volume={5},
  pages={R132 - R139}
}
To examine the effect of transforming growth factor (TGF)-beta1 on the regulation of cartilage synthesis and other articular pathologies, we used adenovirus-mediated intra-articular gene transfer of TGF-beta1 to both naïve and arthritic rabbit knee joints. Increasing doses of adenoviral vector expressing TGF-beta1 were injected into normal and antigen… CONTINUE READING