Adverse effects of 5α-reductase inhibitors: What do we know, don’t know, and need to know?

@article{Traish2015AdverseEO,
  title={Adverse effects of 5$\alpha$-reductase inhibitors: What do we know, don’t know, and need to know?},
  author={Abdulmaged M. Traish and Roberto Cosimo Melcangi and Marco Bortolato and Luis Miguel Garcia-Segura and Michael Zitzmann},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2015},
  volume={16},
  pages={177-198}
}
Steroids are important physiological orchestrators of endocrine as well as peripheral and central nervous system functions. One of the key processes for regulation of these molecules lies in their enzymatic processing by a family of 5α-reductase (5α-Rs) isozymes. By catalyzing a key rate-limiting step in steroidogenesis, this family of enzymes exerts a crucial role not only in the physiological control but also in pathological events. Indeed, both 5α-R inhibition and supplementation of 5… 

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