Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression.

@article{Gardner2009AdverseEL,
  title={Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression.},
  author={Katherine L Gardner and Matthew Hale and Stafford L. Lightman and Paul M. Plotsky and Christopher A Lowry},
  journal={Brain research},
  year={2009},
  volume={1305},
  pages={47-63}
}
Anxiety disorders, depression and animal models of vulnerability to a depression-like syndrome have been associated with dysregulation of serotonergic systems in the brain. To evaluate the effects of early life experience, adverse experiences during adulthood, and potential interactions between these factors on serotonin transporter (slc6a4) mRNA expression, we investigated in rats the effects of maternal separation (180 min/day from days 2 to 14 of life; MS180), neonatal handing (15 min/day… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…