Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder.

@article{Benedetti2014AdverseCE,
  title={Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder.},
  author={Francesco Benedetti and Irene Bollettini and Daniele Radaelli and Sara Poletti and Clara Locatelli and Andrea Falini and Enrico Smeraldi and Cristina Colombo},
  journal={Psychological medicine},
  year={2014},
  volume={44 14},
  pages={3069-82}
}
BACKGROUND Bipolar disorder (BD) is associated with adverse childhood experiences (ACE), which worsen the lifetime course of illness, and with signs of widespread disruption of white matter (WM) integrity in adult life. ACE are associated with changes in WM microstructure in healthy humans. METHOD We tested the effects of ACE on diffusion-tensor imaging (DTI) measures of WM integrity in 80 in-patients affected by a major depressive episode in the course of BD. We used whole-brain tract-based… CONTINUE READING
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