Adverse childhood experiences and clinical severity in bipolar disorder and schizophrenia: A transdiagnostic two-step cluster analysis.

  title={Adverse childhood experiences and clinical severity in bipolar disorder and schizophrenia: A transdiagnostic two-step cluster analysis.},
  author={Elvira Anna Carbone and Valentina Pugliese and Antonella Bruni and Matteo Aloi and Giuseppina Calabr{\`o} and Mar{\'i}a Jos{\'e} Ja{\'e}n-Moreno and Cristina Segura-Garc{\'i}a and Pasquale De Fazio},
  journal={Journal of affective disorders},

Dissociative Symptoms and Psychotic Features in Bipolar Disorder: Impact on Clinical Course and Treatment Response

Several clinical variables transversely indicate a poor response to treatment with mood stabilizers, a worse course of illness, and the presence of dissociative symptoms in patients with bipolar disorder.

Neurocognition and its association with adverse childhood experiences and familial risk of mental illness

The impact of childhood adversity on neurocognition is moderated by familial risk of psychiatric disorders, particularly in FDRs of patients with severe mental illness.

Identification of transdiagnostic psychiatric disorder subtypes using unsupervised learning

The identification of transdiagnostic clusters is identified that psychiatric disorders consist of heterogeneous subtypes sharing molecular factors and symptoms and may support the development of personalized treatments.

Auditory verbal hallucinations and childhood trauma subtypes across the psychosis continuum: a cluster analysis

Different types of childhood trauma had different relationships between clinical and phenomenological features of voice-hearing experiences, implicating different mechanistic pathways and a need for tailored treatment approaches.

The Effect of Traumatic Events on the Longitudinal Course and Outcomes of Youth with Bipolar Disorder.

The Intersection Between Childhood Trauma, the COVID-19 Pandemic, and Trauma-related and Psychotic Symptoms in People With Psychotic Disorders

It is suggested that having a psychotic disorder does not, in and of itself, increase susceptibility to the pandemic’s negative impacts, as well as a graded relationship between cumulative childhood traumatic experiences and the number pandemic adversities, across diagnoses.

Proneness, urbanicity, trauma, and cannabis triggering psychotic states in large urban centers.

It is clear that psychosis is strongly affected by a number of environmental determinants that act in concert with genetic determinants to cause psychotic disorders; however, these influences are complex and their actual impact may be difficult to establish because of poor definitions and specificity.



Childhood trauma is associated with severe clinical characteristics of bipolar disorders.

The results demonstrate consistent associations between childhood trauma and more severe clinical characteristics in bipolar disorder and show the importance of including emotional abuse as well as the more frequently investigated sexual abuse when targeting clinical characteristics of bipolar disorder.

Childhood adversities are different in Schizophrenic Spectrum Disorders, Bipolar Disorder and Major Depressive Disorder

The results support that SSD, BD and MDD are associated to different childhood adversities and suggest that psychosocial interventions that reduce the incidence of these early life adversities might reduceThe incidence of severe and disabling psychiatric disorders.

Anomalous self-experience and childhood trauma in first-episode schizophrenia.

Bipolar Disorder and Early Affective Trauma.

Early trauma is more often found in the past of bipolar adult patients than the general population and studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a worse prognosis.

The Impact of Childhood Adversity on the Clinical Features of Schizophrenia

  • R. Rajkumar
  • Psychology, Medicine
    Schizophrenia research and treatment
  • 2015
Child abuse and neglect in patients with schizophrenia is common and appears to be associated with a specific symptom profile, and certain components of the metabolic syndrome also appear to be related to childhood adversity.

A Network Approach to Psychosis: Pathways Between Childhood Trauma and Psychotic Symptoms

It is suggested that multiple paths may exist between trauma and psychosis and may also be useful in mapping potential transdiagnostic processes.

Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma.

The association between trauma and psychosis is apparent across different levels of illness and vulnerability to psychotic disorder, suggesting true association rather than reporting bias, reverse causality, or passive gene-environment correlation.