Adverse blood transfusion outcomes: establishing causation.

  title={Adverse blood transfusion outcomes: establishing causation.},
  author={James P Isbister and Aryeh S Shander and Donat R Spahn and Jochen Erhard and Shannon Farmer and Axel O Hofmann},
  journal={Transfusion medicine reviews},
  volume={25 2},
The transfusion of allogeneic red blood cells (RBCs) and other blood components is ingrained in modern medical practice. The rationale for administering transfusions is based on key assumptions that efficacy is established and risks are acceptable and minimized. Despite the cliché that, "the blood supply is safer than ever," data about risks and lack of efficacy of RBC transfusions in several clinical settings have steadily accumulated. Frequentist statisticians and clinicians demand evidence… CONTINUE READING

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