Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.

@article{HuizerPajkos2016AdverseGO,
  title={Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.},
  author={Aniko Huizer-Pajkos and Alice Elizabeth Kane and Susan E Howlett and John C Mach and Sarah Jayne Mitchell and Rafael de Cabo and David George Le Couteur and Sarah N Hilmer},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2016},
  volume={71 5},
  pages={
          571-7
        }
}
We aimed to develop a mouse model of polypharmacy, primarily to establish whether short-term exposure to polypharmacy causes adverse geriatric outcomes. We also investigated whether old age increased susceptibility to any adverse geriatric outcomes of polypharmacy. Young (n= 10) and old (n= 21) male C57BL/6 mice were administered control diet or polypharmacy diet containing therapeutic doses of five commonly used medicines (simvastatin, metoprolol, omeprazole, acetaminophen, and citalopram… CONTINUE READING
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