Adverse Events of Antibiotics Used to Treat Acute Otitis Media in Children: A Systematic Meta-Analysis.

  title={Adverse Events of Antibiotics Used to Treat Acute Otitis Media in Children: A Systematic Meta-Analysis.},
  author={Stephanie W Hum and Kai J Shaikh and Samar S Musa and Nader Shaikh},
  journal={The Journal of pediatrics},
OBJECTIVE To characterize the incidence of adverse events (AEs) associated with antibiotics used to treat acute otitis media in children. STUDY DESIGN We searched MEDLINE for studies conducted between January 1, 1966, and August 25, 2018. Two authors independently assessed potential studies and extracted the data. We included published randomized controlled trials, cross-sectional studies, and cohort studies that evaluated the incidence of diarrhea, generalized rash, diaper rash, and candidal… Expand
6 Citations
Update on the adverse effects of antimicrobial therapies in community practice.
Current knowledge of harms from systemic oral antibiotics that are regularly used in family medicine is summarized in this article, finding it difficult to identify and ascribe exact probabilities of most harms. Expand
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Mise à jour sur les effets indésirables des traitements antimicrobiens en pratique communautaire
Resume Objectif Rassembler l’information sur les effets indesirables des antibiotiques, que pourront utiliser les medecins prescripteurs comme reference et ressource d’apprentissage. Qualite desExpand


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Among children 6 to 23 months of age with acute otitis media, reduced-duration antimicrobial treatment resulted in less favorable outcomes than standard-duration treatment; in addition, neither the rate of adverse events nor the rates of emergence of antimicrobial resistance was lower with the shorter regimen. Expand
Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication
The common harms of the most frequently prescribed antibiotic, amoxicillin, from randomized placebo-controlled trials were quantified to inform decisions by helping clinicians to balance harms against benefits. Expand
Comparative safety and efficacy of cefdinir vs. amoxicillin/clavulanate for treatment of suppurative acute otitis media in children
Two dosage regimens of cefdinir were compared with amoxicillin/clavulanate for the treatment of suppurative acute otitis media in children in an investigator-blinded, randomized, comparative, multicenter trial, and data suggest that cef dinir QD may be a better alternative than cefinir BID for refractory AOM. Expand
Acute otitis media, antimicrobial prescriptions, and medical expenses among children in the United States during 2011-2016.
AOM incidence, antimicrobial prescriptions, and associated medical expenses decreased substantially between 2011 and 2016 in the United States, and Antimicrobial prescribing practices remain unchanged. Expand
Adverse Drug Reactions in Children—A Systematic Review
A systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community, provides estimates of incidence in different settings and some indication of the therapeutic classes most frequently associated with ADRs. Expand
A Multicenter, Open Label, Double Tympanocentesis Study of High Dose Cefdinir in Children With Acute Otitis Media at High Risk of Persistent or Recurrent Infection
Large dose cefdinir resulted in an overall successful clinical response at end of treatment of 83%. Expand
The diagnosis and management of acute otitis media.
This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians.Expand
The Diagnosis and Management of Acute Otitis Media
This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians.Expand
Reporting of adverse effects in clinical trials should be improved: lessons from acute postoperative pain.
Assessment and reporting of adverse effects in randomized, double-blind clinical trials of single-dose acetaminophen or ibuprofen compared with placebo in moderate to severe postoperative pain found that different methods of assessing adverse effects produce different reported incidence. Expand
Reducing antibiotic use in children: a randomized trial in 12 practices.
A limited simultaneous educational outreach intervention for parents and providers reduced antibiotic use among children in primary care practices, even in the setting of substantial secular trends toward decreased prescribing. Expand