Adverse Events After the Use of Benznidazole in Infants and Children With Chagas Disease

@article{Altcheh2011AdverseEA,
  title={Adverse Events After the Use of Benznidazole in Infants and Children With Chagas Disease},
  author={Jaime Altcheh and Guillermo Moscatelli and Samanta Moroni and Facundo Garcia-Bournissen and H{\'e}ctor L. Freilij},
  journal={Pediatrics},
  year={2011},
  volume={127},
  pages={e212 - e218}
}
BACKGROUND: Chagas disease is caused by infection with Trypanosoma cruzi. In adults, treatment with benznidazole is associated with a high incidence of adverse drug reactions (ADRs). However, in infants and children, treatment with benznidazole seems associated with a lower incidence and decreased severity of ADRs, but these effects have not been clearly characterized. OBJECTIVE: We aimed to describe ADRs observed in infants and children treated with benznidazole. PATIENTS AND METHODS: We… 
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TLDR
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TLDR
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TLDR
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Antitrypanosomal therapy for chronic Chagas' disease.
TLDR
Significant lower blood concentrations of the drug in children than those reported in adults receiving the same dose per kilogram of body weight are observed, suggesting that lower clearance of benznidazole in adults leads to drug accumulation and a higher rate of adverse events.
Safety Profile of Benznidazole in the Treatment of Chronic Chagas Disease: Experience of a Referral Centre and Systematic Literature Review with Meta-Analysis
TLDR
Benznidazole had a poor tolerability profile, with a high incidence of TDs, especially in adult patients and women, and optimised dosing schedules and/or new drugs are urgently needed.
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