Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

@article{Sheen2010AdverseEO,
  title={Adverse Effects of Long-Term Proton Pump Inhibitor Therapy},
  author={Edward Sheen and George Triadafilopoulos},
  journal={Digestive Diseases and Sciences},
  year={2010},
  volume={56},
  pages={931-950}
}
Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency… 

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