Adverse Effects from Clenbuterol and Ractopamine on Nematode Caenorhabditis elegans and the Underlying Mechanism

@article{Zhuang2014AdverseEF,
  title={Adverse Effects from Clenbuterol and Ractopamine on Nematode Caenorhabditis elegans and the Underlying Mechanism},
  author={Ziheng Zhuang and Yunli Zhao and Qiuli Wu and M. Li and Haicui Liu and Lingmei Sun and W. Gao and Dayong Wang},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
In the present study, we used Caenorhabditis elegans assay system to investigate in vivo toxicity from clentuberol and ractopamine and the possible underlying mechanism. Both acute and prolonged exposures to clentuberol or ractopamine decreased brood size and locomotion behavior, and induced intestinal autofluorescence and reactive oxygen species (ROS) production. Although acute exposure to the examined concentrations of clentuberol or ractopamine did not induce lethality, prolonged exposure to… Expand
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