Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents

@article{Benitez2019AdverseEA,
  title={Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents},
  author={Lydia L. Benitez and Peggy L Carver},
  journal={Drugs},
  year={2019},
  volume={79},
  pages={833-853}
}
Azole antifungals are first-line options in the prophylaxis and treatment of invasive fungal infections. They are often used for prolonged (weeks to months) periods of time, particularly in patients with hematologic malignancies, or in those who have received a solid organ or hematopoietic stem cell transplant. Long-term use of azoles is associated with hepatotoxicity and hormone-related effects, including gynecomastia, alopecia, decreased libido, oligospermia, azoospermia, impotence… 

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