Adverse Drug Reactions in Herding-Breed Dogs : The Role of P-Glycoprotein *

@inproceedings{Vinblastine2006AdverseDR,
  title={Adverse Drug Reactions in Herding-Breed Dogs : The Role of P-Glycoprotein *},
  author={• Vinblastine and Ketoconazole • Itraconazole and Talinolol},
  year={2006}
}
  • • Vinblastine, Ketoconazole • Itraconazole, Talinolol
  • Published 2006
P-glycoprotein, encoded by the MDR1 gene, plays an important role in the absorption, distribution, metabolism, and excretion of many drugs.Thus it is not surprising that lack of P-glycoprotein, which occurs in many herding-breed dogs, leads to increased susceptibility to drug toxicosis (e.g., use of ivermectin and other drug sensitivities in collies). By using a genetic test, it is now possible to predict which dogs will experience drug sensitivity and which will tolerate routine doses of drugs… CONTINUE READING