Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers

@article{Tietjen2012AdverseCE,
  title={Adverse Childhood Experiences Are Associated With Migraine and Vascular Biomarkers},
  author={Gretchen E. Tietjen and Jagdish Khubchandani and Nabeel A Herial and Kavit Shah},
  journal={Headache: The Journal of Head and Face Pain},
  year={2012},
  volume={52}
}
Objectives.— Migraine is a risk factor for stroke in young women. Biomarker studies implicate endothelial activation as a possible mechanism. Emerging relationships of childhood adversity with migraine, and with inflammation, a component of endothelial activation, suggest that it may play a role in the migraine–stroke association. Our objective is to evaluate the relationship between adverse childhood experiences (ACEs), migraine, and vascular biomarker levels in premenopausal women. 
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75 Citations

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References

SHOWING 1-10 OF 42 REFERENCES

Adverse Childhood Experiences and Frequent Headaches in Adults

This study assesses the relationship of adverse childhood experiences (ACEs) to frequent headaches during adulthood and finds that childhood maltreatment is linked to headache severity during adulthood.

Migraine and Biomarkers of Endothelial Activation in Young Women

In premenopausal women with migraine, particularly in those with MA, there is evidence of increased endothelial activation, a component of endothelial dysfunction.

Migraine frequency and risk of cardiovascular disease in women

In this cohort study of 27,798 US women aged ≥45 years, the association between migraine and cardiovascular disease varies by migraine frequency, with significant associations found among women with migraine with aura.

Association between childhood physical abuse and gastrointestinal disorders and migraine in adulthood.

This work hypothesized that childhood physical abuse would be associated with increased odds of gastrointestinal disorders and migraine headache during adulthood, and that this association would be independent of comorbid mental disorders.

Endocrine Function Is Altered in Chronic Migraine Patients with Medication‐Overuse

Objective.—To evaluate the effects of analgesic overuse on endocrine function in patients with chronic migraine and medication‐overuse headache (CM‐MOH).

Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis.

Headache and biomarkers predictive of vascular disease in a representative sample of US children.

Examination of childhood headache disorders with markers of risk for cardiovascular and cerebrovascular disease found several important risk factors for long-term vascular morbidity cluster in children and adolescents with severe or recurrent headache or migraine.

Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers.

Children exposed to adverse psychosocial experiences have enduring emotional, immune, and metabolic abnormalities that contribute to explaining their elevated risk for age-related disease.

Biological embedding of stress through inflammation processes in childhood

It is found that children experiencing maltreatment and depression showed significantly elevated inflammation levels, regardless of their socioeconomic status, gender, zygosity, body temperature and waist–hip ratio, which are consistent with studies reviewed elsewhere.

Migraine and cardiovascular disease: systematic review and meta-analysis

Migraine is associated with a twofold increased risk of ischaemic stroke, which is only apparent among people who have migraine with aura, and the results suggest a higher risk among women and risk was further magnified for people with migraine who were aged less than 45, smokers, and women who used oral contraceptives.