Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis.

@article{Matsushita2012AdvantagesOH,
  title={Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis.},
  author={Ayuko Matsushita and Masahiro Seike and Haruka Okawa and Yayoi Kadawaki and Hiroshi Ohtsu},
  journal={Experimental dermatology},
  year={2012},
  volume={21 9},
  pages={
          714-5
        }
}
Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine… CONTINUE READING
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