Advantages and Disadvantages of Etomidate Use for Intubation of Patients with Sepsis

  title={Advantages and Disadvantages of Etomidate Use for Intubation of Patients with Sepsis},
  author={Antoine J. Cherfan and Y. Arabi and H. Al-Dorzi and Lisa P. Kenny},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Etomidate is a potent imidazole hypnotic used widely in single doses in the rapid sequence intubation of critically ill patients with sepsis due to its presumed hemodynamic safety, fast onset, and short duration of action. However, the literature is conflicting regarding the hemodynamic advantages of etomidate over other induction agents, and its safety in this population is a matter of strong debate in the critical care community as the drug is associated with suppression of adrenal… Expand
16 Citations
Pro: etomidate is the ideal induction agent for a cardiac anesthetic.
  • A. Budde, B. Mets
  • Medicine
  • Journal of cardiothoracic and vascular anesthesia
  • 2013
  • 18
Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock
  • 13
Clinical study of etomidate emulsion combined with remifentanil in general anesthesia
  • 5
  • PDF
Continuous-Infusion Etomidate in a Patient Receiving Extracorporeal Membrane Oxygenation.
  • 1
Etomidate Use Is Associated With Less Hypotension Than Ketamine for Emergency Department Sepsis Intubations: A NEAR Cohort Study
  • 3


A review of etomidate for rapid sequence intubation in the emergency department.
  • 107
  • PDF
The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock
  • 169
  • PDF
Outcomes of etomidate in severe sepsis and septic shock.
  • 32
Duration of adrenal inhibition following a single dose of etomidate in critically ill patients
  • 126
A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study.
  • 63
  • Highly Influential
  • PDF
Controversies Surrounding the Use of Etomidate for Rapid Sequence Intubation in Patients with Suspected Sepsis
  • 23
The effect of etomidate on adrenal function in critical illness: a systematic review
  • 123
  • PDF
Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial
  • 233
  • Highly Influential
  • PDF