Advancing the activity cliff concept

@inproceedings{Hu2013AdvancingTA,
  title={Advancing the activity cliff concept},
  author={Ye Hu and Dagmar Stumpfe and J{\"u}rgen Bajorath and Meir Glick and Patrick Walters and Gerhard M{\"u}ller},
  booktitle={F1000Research},
  year={2013}
}
The activity cliff concept has experienced increasing interest in medicinal chemistry and chemoinformatics. Activity cliffs have originally been defined as pairs of structurally similar compounds that are active against the same target but have a large difference in potency. Activity cliffs are relevant for structure-activity relationship (SAR) analysis and compound optimization because small chemical modifications can be deduced from cliffs that result in large-magnitude changes in potency. In… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Similar Papers

Loading similar papers…