Advancing science and technology via 3D culture on basement membrane matrix.

  title={Advancing science and technology via 3D culture on basement membrane matrix.},
  author={Gabriel Benton and Joseph George and Hynda K. Kleinman and Irina Arnaoutova},
  journal={Journal of cellular physiology},
  volume={221 1},
Many cells in tissues are in contact with a highly specialized extracellular matrix, termed the basement membrane. Basement membranes have certain common components, including collagen IV, laminins, heparan sulfate proteoglycans, and growth factors which have a wide variety of biological activities. Extracts of basement membrane-rich tissue have yielded material suitable for studying cell-basement membrane interactions. Cells cultured in a 3D basement membrane matrix allow the in vitro modeling… CONTINUE READING


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