Advancing paternal age and the risk of schizophrenia.

@article{Malaspina2001AdvancingPA,
  title={Advancing paternal age and the risk of schizophrenia.},
  author={Dolores Malaspina and Susan Harlap and Shumel Fennig and Donald F. Heiman and D. Mimran Nahon and Daniel I. Feldman and Ezra S Susser},
  journal={Archives of general psychiatry},
  year={2001},
  volume={58 4},
  pages={
          361-7
        }
}
BACKGROUND A major source of new mutations in humans is the male germ line, with mutation rates monotonically increasing as father's age at conception advances, possibly because of accumulating replication errors in spermatogonial cell lines. METHOD We investigated whether the risk of schizophrenia was associated with advancing paternal age in a population-based birth cohort of 87 907 individuals born in Jerusalem from 1964 to 1976 by linking their records to the Israel Psychiatric Registry… CONTINUE READING

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