Advancing islet transplantation: from engraftment to the immune response

  title={Advancing islet transplantation: from engraftment to the immune response},
  author={Romie F Gibly and John G I Graham and Xuegang Luo and William L. Lowe and Bernhard J. Hering and Lonnie D Shea},
The promise and progress of islet transplantation for treating type 1 diabetes has been challenged by obstacles to patient accessibility and long-term graft function that may be overcome by integrating emerging technologies in biomaterials, drug delivery and immunomodulation. The hepatic microenvironment and traditional systemic immunosuppression stress the vulnerable islets and contribute to the limited success of transplantation. Locally delivering extracellular matrix proteins and trophic… CONTINUE READING
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