Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.

@article{Wyrobek2006AdvancingAH,
  title={Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.},
  author={Andrew J. Wyrobek and Brenda Eskenazi and Sarah Young and Norman Arnheim and Irene Tiemann-Boege and Ethylin Wang Jabs and Rivka L. Glaser and Francesca S Pearson and Donald P. Evenson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 25},
  pages={9601-6}
}
This study compares the relative effects of advancing male age on multiple genomic defects in human sperm [DNA fragmentation index (DFI), chromatin integrity, gene mutations, and numerical chromosomal abnormalities], characterizes the relationships among these defects and with semen quality, and estimates the incidence of susceptible individuals for a well characterized nonclinical nonsmoking group of 97 men (22-80 years). Adjusting for confounders, we found major associations between age and… CONTINUE READING
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