Advancing a clinically relevant perspective of the clonal nature of cancer.

  title={Advancing a clinically relevant perspective of the clonal nature of cancer.},
  author={Christian Ruiz and Elizabeth Lenkiewicz and Lisa Evers and Tara K. Holley and Alex Robeson and Jeffrey A. Kiefer and Michael J. Demeure and Michael Anthony Hollingsworth and Michael Shen and Donna Prunkard and Peter S. Rabinovitch and Tobias Zellweger and Spyro Mousses and Jeffrey M. Trent and John D. Carpten and Lukas Bubendorf and Daniel Von Hoff and Michael T. Barrett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 29},
Cancers frequently arise as a result of an acquired genomic instability and the subsequent clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the presence and behaviors of distinct clonal populations in each patient's tumor may underlie multiple clinical phenotypes in cancers. We applied DNA content-based flow sorting to identify and isolate the nuclei of clonal populations from tumor biopsies, which was coupled with array CGH and targeted resequencing… CONTINUE READING
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