Advances of Immune Checkpoint Inhibitors in Tumor Immunotherapy

  title={Advances of Immune Checkpoint Inhibitors in Tumor Immunotherapy},
  author={Qiao Guo},
Immune checkpoints are cell surface molecules that can fine-tune the immune responses, they are crucial for modulating the duration and amplitude of immune reactions while maintaining self-tolerance in order to minimize autoimmune responses. Numerous studies have demonstrated that tumors cells can directly express immune-checkpoint molecules, or induce many inhibitory molecules expression in the tumor microenvironment to inhibit the anti-tumor immunity. Releasing these brakes has emerged as an… CONTINUE READING

Topics from this paper.