Advances in vaccine adjuvants

@article{Singh1999AdvancesIV,
  title={Advances in vaccine adjuvants},
  author={Manmohan J. Singh and Derek T. O’hagan},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={1075-1081}
}
Currently, aluminum salts and MF59 are the only vaccine adjuvants approved for human use. With the development of new-generation vaccines (including recombinant subunit and mucosal vaccines) that are less immunogenic, the search for more potent vaccine adjuvants has intensified. Of the novel compounds recently evaluated in human trials, immunostimulatory molecules such as the lipopolysaccharide derived MPL and the saponin derivative QS21 appear most promising, although doubts have been raised… 
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