Advances in understanding the leukaemia microenvironment.

  title={Advances in understanding the leukaemia microenvironment.},
  author={Yoko Tabe and Marina Konopleva},
  journal={British journal of haematology},
  volume={164 6},
Dynamic interactions between leukaemic cells and cells of the bone marrow are a feature of haematological malignancies. Two distinct microenvironmental niches in the bone marrow, the 'osteoblastic (endosteal)' and 'vascular' niches, provide a sanctuary for subpopulations of leukaemic cells to evade chemotherapy-induced death and allow acquisition of drug resistance. Key components of the bone marrow microenvironment as a home for normal haematopoietic stem cells and the leukaemia stem cell… CONTINUE READING
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