Advances in understanding cancer genomes through second-generation sequencing

  title={Advances in understanding cancer genomes through second-generation sequencing},
  author={M. Meyerson and S. Gabriel and G. Getz},
  journal={Nature Reviews Genetics},
  • M. Meyerson, S. Gabriel, G. Getz
  • Published 2010
  • Biology, Medicine
  • Nature Reviews Genetics
  • Cancers are caused by the accumulation of genomic alterations. Therefore, analyses of cancer genome sequences and structures provide insights for understanding cancer biology, diagnosis and therapy. The application of second-generation DNA sequencing technologies (also known as next-generation sequencing) — through whole-genome, whole-exome and whole-transcriptome approaches — is allowing substantial advances in cancer genomics. These methods are facilitating an increase in the efficiency and… CONTINUE READING
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