Advances in understanding benzene health effects and susceptibility.

@article{Smith2010AdvancesIU,
  title={Advances in understanding benzene health effects and susceptibility.},
  author={Martyn T. Smith},
  journal={Annual review of public health},
  year={2010},
  volume={31},
  pages={
          133-48 2 p following 148
        }
}
  • Martyn T. Smith
  • Published 2010
  • Biology, Medicine
  • Annual review of public health
Benzene is a ubiquitous chemical in our environment that causes acute leukemia and probably other hematological cancers. Evidence for an association with childhood leukemia is growing. Exposure to benzene can lead to multiple alterations that contribute to the leukemogenic process, indicating a multimodal mechanism of action. Research is needed to elucidate the different roles of multiple metabolites in benzene toxicity and the pathways that lead to their formation. Studies to date have… Expand
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TLDR
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The findings suggest that chronic benzene exposure, even at levels below the current U.S. occupational standard, perturbs many genes, biological processes, and pathways and reveals relevant potential biomarkers associated with a range of exposures. Expand
Increased leukemia-associated gene expression in benzene-exposed workers
TLDR
It is suggested that CNVs and leukemia-related gene expression might play roles in leukemia development in benzene-exposed workers. Expand
Assessing biomarkers on exposure, effects and susceptibility for environmental and occupational exposure of various range of benzene
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A clandestine culprit with critical consequences: Benzene and acute myeloid leukemia.
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It is possible that ambient benzene may contribute to many cases of "de novo" AML not arising out of germline predispositions, and the association between chronic, low-dose and ambient exposure to environmental benzene and the development of adult AML is discussed. Expand
Current understandings and perspectives on non-cancer health effects of benzene: a global concern.
OBJECTIVE Benzene, as a volatile organic compound, is known as one of the main air pollutants in the environment. The aim of this review is to summarize all available evidences on non-cancerousExpand
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References

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TLDR
Observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals. Expand
Hematotoxicity in Workers Exposed to Low Levels of Benzene
TLDR
Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity and may be particularly evident among genetically susceptible subpopulations. Expand
THE ROLE OF METABOLISM AND SPECIFIC METABOLITES IN BENZENE-INDUCED TOXICITY: EVIDENCE AND ISSUES
  • David Ross
  • Chemistry, Medicine
  • Journal of toxicology and environmental health. Part A
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TLDR
This review is not intended to be a comprehensive review of benzene metabolism but focuses on a critical appraisal of potential metabolic mechanisms underlying benzene toxicity, important questions that remain to be answered, and potential future directions for research. Expand
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TLDR
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TLDR
Risks of acute myeloid leukemia and other malignant and nonmalignant hematopoietic disorders associated with benzene exposure in China are consistent with other information about Benzene exposure, hematotoxicity, and cancer risk, extending evidence for hematocancer cancer risks to levels substantially lower than had previously been established. Expand
Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
TLDR
It is suggested that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. Expand
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TLDR
The evidence supports an association between occupational benzene exposure and NHL and a substantial healthy-worker effect was evident in many of the studies and a comprehensive reevaluation of these studies with appropriate adjustments should be undertaken. Expand
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TLDR
This study investigated the involvement of the aryl hydrocarbon receptor (AhR) in benzene hematotoxicity using AhR wild-type, heterozygous, and homozygous male mice and found the unique possibility that the benzene toxicity may be regulated by AhR signaling. Expand
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TLDR
Findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time. Expand
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TLDR
In leukemia cases associated with benzene exposure, there is no evidence of a unique pattern of benzene-induced chromosomal aberrations in humans, and firm conclusions cannot be made about the involvement of specific chromosomes or chromosome regions. Expand
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