Advances in the understanding of the mechanism of action of IVIg

  title={Advances in the understanding of the mechanism of action of IVIg},
  author={Prof. Dr. Hans-Peter Hartung},
  journal={Journal of Neurology},
The IgG molecule is the main component of IVIg. Commercial preparations of IVIg are derived from a pool of donors and subsequently, IVIg products contain smaller amounts of IgA and IgM antibodies as well as Th2 cytokines and cytokine antagonists that may also contribute to therapeutic effects. Numerous targets for IVIg include: T-cells, cytokines, immune cell trafficking, B-cells, complement and Fc-receptors. IVIg has been demonstrated to inactivate auto-reactive T-cells by competing for and… CONTINUE READING
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