Advances in the understanding of myeloma bone disease and tumour growth.

@article{Yaccoby2010AdvancesIT,
  title={Advances in the understanding of myeloma bone disease and tumour growth.},
  author={Shmuel Yaccoby},
  journal={British journal of haematology},
  year={2010},
  volume={149 3},
  pages={311-21}
}
Advances in multiple myeloma support the notion that the associated bone disease, characterized by increased osteoclastogenesis and suppressed osteoblastogenesis, is both a consequence and necessity of tumour progression. Osteoblastogenesis is suppressed by secreted inhibitors and dysregulation of cell-surface 'coupling' factors on osteogenic cells. Osteoclastogenesis is increased as a consequence of osteoblast deactivation and of production of osteoclast-activating factors. Osteoclasts express… CONTINUE READING

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