Advances in the treatment of relapsed acute promyelocytic leukemia.

  title={Advances in the treatment of relapsed acute promyelocytic leukemia.},
  author={Dan Douer},
  journal={Acta haematologica},
  volume={107 1},
  • Dan Douer
  • Published 2002 in Acta haematologica
The presence of the characteristic fusion transcript gene, promyelocytic leukemia-retinoic acid receptor-alpha (PML-RARalpha), provided hematologists with a rationale for the use of all-trans retinoic acid (ATRA) for differentiation therapy for acute promyelocytic leukemia (APL). Multiple studies have established that combination of ATRA and chemotherapy in newly diagnosed patients has increased the cure rate to 70% from 35% in patients treated with chemotherapy alone. However, still about 30… CONTINUE READING
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